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Police are appealing for witnesses to a serious collision between a car and lorry on the A23 near Bolney around 5.15am on Sunday (July 10).
The road is currently closed in both directions from Junction 11 (Pease Pottage) while police, fire and ambulance services attend the scene.
It is likely the road is going to be closed in both directions for a significant time and it is not yet known when the road will re-open.
Anyone who was planning to use the road is being asked to take an alternative route.
Anyone who witnessed the collision or has dash cam footage of it is asked to report it to police by emailing it to collision.appeal@sussex.police.uk or call 101 quoting Operation Riverhill.